Algen is using advanced CRISPR gene-modulation and AI to reverse human disease trajectory for discovery and development of precision medicines to extend healthspan.
BIOIO develops mechanism of action based therapies for aging. The lead asset, BIOIO-1001, is an insulin sensitizer in development for the treatment of type 2 diabetes mellitus.
Bolden Therapeutics is developing first-in-class therapeutics to increase neurogenesis and improve outcomes in neurological disease.
Deciduous Therapeutics is developing novel immunotherapies that activate the body's immune system to target and eliminate pathogenic senescent cells, offering promising treatments for age-related diseases and overall improvements in health-span.
EpiBone, Inc. is a privately held clinical-stage regenerative medicine company focused on skeletal reconstruction.
Fauna Bio is a first-of-its-kind biotech company that studies the protective genotypes across extreme biology to develop new therapies to improve human health and lifespan.
The next generation of induced proximity medicines.
Immunis, Inc. is a clinical-stage biotechnology company based in Irvine, CA, developing novel, multi-active biologics to address age- and disease-related immune dysregulation.
Unravelling complex biology with optogenetics, chemistry and computation for small molecule discovery in age-related diseases.
LIfT Biosciences is a biotech bringing to market a first-in-class alpha neutrophil-based immunotherapy that overcomes the limitations of current therapies in solid tumours by destroying tumours both directly and indirectly.
Marble Therapeutics is a biotechnology company with an overarching goal to pioneer real-world rejuvenation and enhancement products through a first-in-kind causal inference understanding of nonlinear dynamics in biology.
Matter Bio is a longevity holding company focused on quantifying and reversing DNA damage to prevent diseases of aging and increase healthy lifespan.
Modulo is a platform driven biotech startup focused on developing therapies that reprogram the brain’s immune system to slow or reverse neurological diseases.
NaNotics is a biopharmaceutical company developing NaNots™, novel subtractive nanoparticles that treat disease by capturing and clearing pathogenic molecules from blood.
Paulex Bio is developing oral medicines to regenerate pancreatic islet beta-cells and restore normal insulin production.
PriveBio is a precision medicine biotech discovering and developing novel medicines improving healthspan by curing fibro-inflammation in cardiorenal diseases and obesity in the post-GLP1 era.
Rejuvenate Bio is a spinout from the Wyss Institute at Harvard focused on reversing aging and eliminating age-related disease. Rejuvenate Bio utilizes gene therapy, proprietary targets, and tools to bring treatments to patients suffering from age-related conditions.
Rejuvenation Technologies is developing mRNA therapies to treat aging biology and related diseases. The company uses lipid nanoparticles to deliver telomerase mRNA to restore telomere length and tissue regenerative capacity.
Remedium Bio is bringing the curative potential of genetic medicine to large unmet needs, affecting how we live and age through application of our first-in-class Prometheus™ adjustable-dose gene therapy platform.
SENISCA has identified a new, druggable molecular cause of cellular ageing (senescence): RNA splicing dysregulation. The Company is developing oligonucleotide senotherapeutics that target splicing regulation, resulting in cellular reprogramming and disease modification by attenuating senescence.
Sift Biosciences is developing a peptide-based immunotherapy platform designed to harness pre-existing immune memory.
TECregen is advancing immuno-rejuvenation with next-generation therapies that regenerate thymus function, restoring T-cell production and durable immune balance to address age-related immune decline.
Violet Therapeutics is developing first-in-class small molecule therapies for CNS diseases by mapping disease-relevant cell-to-cell signaling interactions in the brain to support synaptic repair and cognitive function.
